Abstract Toxicology publications

updated Jun 09, 2011 by Pouokam Guy Bertrand

Journal of Toxicology and Environmental Health Sciences Vol. 3(5), pp. 119-126, May 2011 ISSN 2006-9820 ©2011 Academic Journals
	Full Research Paper
Influence of age on sub-chronic toxicity of the aqueous extract of the leaves of *Calotropis procera* on rabbits Pouokam Guy B.¹, Hatem Ahmed², Christianna Dawurung³, Aliyu Atiku³ Shamaki David⁴ and Okewole Philipe⁴ ¹Laboratory of Food Sciences and Metabolisms, Department of Biochemistry, University of Yaoundé 1, Cameroon. ²Chemical Laboratory, Medico-Legal Department, Ministry of Justice, Egypt. ³Toxicology Unit, Department of Biochemistry, National Veterinary Research Institute, Nigeria. ⁴Center Diagnosis: National Veterinary Research Institute, Nigeria. Corresponding author: E-mail: pouokam_guy@yahoo.fr. Accepted 15 April, 2011

Abstract
Calotropis procera is of the family Asclepiadaceae. The whole plant is toxic. The influence of age on sub-chronic toxicity of aqueous leaves extract was investigated in New Zealand White X local breed rabbits (Oryctolagus cuniculus) of both sexes. 200 mg/kg body weight of the extract was daily administered orally by gavages during 42 days. Vital signs, body weight change, mortality, serum biochemistry, hematology parameters, necropsy and histopathology were examined. All the rabbits gained weight during the administration period, with an appreciable gain for smaller animals. Significant decrease (p<0.05) of ALT and RBC were noticed in the youngest rabbits. A significant increase (p<0.05) of serum creatinine level and lymphocytes were also noticed within the group of the juvenile rabbits. Necropsy revealed lesions in kidney and liver, these lesions were further confirmed by histopathology observations that revealed more pronounced pathology with the youngest animals. Although animals in different test groups show some toxic effects; small animals of eight weeks exhibit more effects with more severe lesions. Key words: Age, Asclepiadaceae, histopathology, toxicity.

| Journal of Toxicology and Environmental Health Sciences Vol. 3(5), pp. 119\-126, May 2011\\
ISSN 2006-9820 ©2011 Academic Journals&nbsp;&nbsp; |
| | \\ \\ \\
{color:#df2323}{_}Full Research Paper{_}{color}\\ |
| *Influence of age on sub-chronic toxicity of the* *{_}a{_}{*}{*}queous extract of the leaves of* *{_}Calotropis procera{_}* *on rabbits*\\ \\
*Pouokam Guy B.*{*}{^}1{^}{*}*\*, Hatem Ahmed{*}{*}{^}2{^}{*}*, Christianna Dawurung{*}{*}{^}3{^}{*}*, Aliyu Atiku{*}{*}{^}3{^}*\\
*Shamaki David{*}{*}{^}4{^}* *and Okewole Philipe{*}{*}{^}4{^}*\\ \\
^1{^}Laboratory of Food Sciences and Metabolisms, Department of Biochemistry, University of Yaoundé 1, Cameroon.\\
^2{^}Chemical Laboratory, Medico-Legal Department, Ministry of Justice, Egypt.\\
^3{^}Toxicology Unit, Department of Biochemistry, National Veterinary Research Institute, Nigeria.\\
^4{^}Center Diagnosis: National Veterinary Research Institute, Nigeria.\\ \\
\*Corresponding author: E-mail: pouokam_guy@yahoo.fr.\\ \\
Accepted 15 April, 2011 |
| |
| {color:#ffffff}{*}Abstract{*}{color} |
| \\ \\
_Calotropis procera_ is of the family Asclepiadaceae. The whole plant is toxic. The influence of age on sub-chronic toxicity of aqueous leaves extract was investigated in New Zealand White X local breed rabbits (_Oryctolagus cuniculus_) of both sexes. 200 mg/kg body weight of the extract was daily administered orally by gavages during 42 days. Vital signs, body weight change, mortality, serum biochemistry, hematology parameters, necropsy and histopathology were examined. All the rabbits gained weight during the administration period, with an appreciable gain for smaller animals. Significant decrease (p<0.05) of ALT and RBC were noticed in the youngest rabbits. A significant increase (p<0.05) of serum creatinine level and lymphocytes were also noticed within the group of the juvenile rabbits. Necropsy revealed lesions in kidney and liver, these lesions were further confirmed by histopathology observations that revealed more pronounced pathology with the youngest animals. Although animals in different test groups show some toxic effects; small animals of eight weeks exhibit more effects with more severe lesions. \\ \\
*Key words:* Age, Asclepiadaceae, histopathology, toxicity. | |

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