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Dimethylformamide is a clear liquid, miscible with water and majority of organic solvents and it is used as a solvent in the production of fibers, films, and surface coatings (#EPA).


Just the facts

Physical Information

Name: N,N-Dimethylformamide

Use: solvent

Source: synthetic chemistry

Recommended daily intake: none

Absorption: dermal, ingestion, inhalation

Sensitive individuals: workers

Chemical Structure


Chemical Description

N,N_Dimethylformamide is a colorless liquid at room temperature that is soluble in most solvents and water and is very stable (#INCHEM).

Uses and Benefits

Dimethylformamide is used as a commercial solvent during the synthesis of vinyl resins, adhesives, pesticide formulations, and epoxy formulations; for purification and/or separation of acetylene, 1,3-butadiene, acid gases, and aliphatic hydrocarbons; and in the production of polyacrylic or cellulose triacetate fibers and pharmaceuticals (#INCHEM).

Health Effects

Acute Effects
Symptoms of acute exposure in humans include abdominal pain, nausea, vomiting, jaundice, alcohol intolerance, and rashes (#EPA).

Chronic Effects
Chronic (long-term) occupational exposure to dimethylformamide by inhalation has resulted in effects on the liver and digestive disturbances in workers. (#EPA).

Human Studies have shown a possible link to cancer from chronic, occupational exposure to dimethylformamide.

External Links


International Programme on Chemical Safety. Concise International Chemical Assessment Document 31 N,N-DIMETHYLFORMAMIDE. Accessed 5-16-07.

Environmental Protection Agency. N,N-Dimethylformamide. Accessed 5-17-07.

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