Reviews of Specific Databases and Ready References



Judson R., et al. 2008. ACToR—aggregated computational toxicology resource. Toxicology & Applied Pharmacology. 233(1):7-13.

Judson R.S., et al. 2012. Aggregating data for computational toxicology applications: The US Environmental Protection Agency (EPA) aggregated computational toxicology resource (ACToR) system. International Journal of Molecular Sciences. 13(2):1805-1831.

Aerospace Database

Kavanagh S.K. and Miller J.G. 1986. First Look--The Aerospace Database. Database. 9(2).61-7.

Rao K.N. and Talwar V.G. 2011. Content-based document recommender system for aerospace grey literature: System design. DESIDOC Journal of Library & Information Technology. 31(3):189-201.


Brooks K. 1980. A Comparison of the Coverage of Agricultural and Forestry Literature on AGRICOLA, BIOSIS, CAB, and SCISEARCH. Database. 3(1):38-49.

Edwards S. 1993. Indexing Practices at the National Agricultural Library. Cataloging & Classification Quarterly. 16(3):89-97.

Gilreath C.L. 1978. AGRICOLA: multipurpose data base for agricultural and life sciences libraries. The Serials Librarian. 3(1):89-95.

Kreilkamp H.D. 1977. The National Agricultural Library's Data Base: AGRICOLA. College & Research Libraries. 38(4):298-303.


Anibaldi S., et al. 2015. Migrating bibliographic datasets to the Semantic Web: The AGRIS case. Semantic Web. 6(2):113-120.

Caponio J.F. and Moran L. 1975. Agris. Science. 187(4173):233-236.

Simmons W. 1986. The development of AGRIS: a review of the United States response. Quarterly bulletin (IAALD).


Bingli L., et al. 2008. Prediction of the environmental fate and aquatic ecological impact of nitrobenzene in the Songhua River using the modified AQUATOX model. Journal of Environmental Sciences. 20(7): 769-777.


Pilli, A., et al. 1989. AQUIRE: Aquatic Toxicity Information Retrieval Data Base. Technical Support Document. Duluth, MN: U.S. EPA Environmental Research Laboratory.


Russom C.L., et al. 1991. ASTER: An integration of the AQUIRE data base and the QSAR system for use in ecological risk assessments. Science of the Total Environment. 109:667-670.

ATSDR Toxicological Profiles

Murray H.E. and Thayer K.A. 2014. Implanting systematic review in toxicological profiles: ATSDR and NIEHS/NTP collaboration. Journal of Environmental Health. 76(8):34-5.




Drake N.L. 1930. A Brief Introduction to the Use of Beilstein's Handbuch der Organischen Chemit. Journal of Chemical Education. 7(6).1447.

Bibra Toxicity Profiles


Howard P.H., et al. 1991. Development of a predictive model for biodegradability based on BIODEG, the evaluated biodegradation data base. Science of the Total Environment. 109:635-641.


Howard P.H., et al. 1986. BIOLOG, BIODEG, and FATE/EXPOS: New files on microbial degradation and toxicity as well as environmental fate/exposure of chemicals. Environmental Toxicology & Chemistry. 5(11):977-988.


Barnes S. and McCue J. 1992. Linking library records to bibliographic databases: an analysis of common data elements in BIOSIS, Agricola, and the OPAC. Cataloging & Classification Quarterly. 13(3-4):157-187.

Freedman B. 1995. Growth and change in the world’s biological literature as reflected in BIOSIS publications. Publishing Research Quarterly. 11(3):61-79.

Steere W., editor. 2012. Biological Abstracts/BIOSIS: The First Fifty Years. The Evolution of a Major Science Information Service. New York: Springer Science & Business Media.

Tomezsko G. 2011. Fully Occupied Years: The Rise and Fall of a Company Called BIOSIS. Bloomington, IN: Xlibris Corporation.




Tancredi S.A., et al. 1976. CANCERLINE: A New NLM/NCI Data Base. Journal of chemical information and computer sciences. 16(3): 128-130.


Kjellander E., et al. 1985. Usefulness of the on-line data base CANCERLIT: an evaluation study based on consecutive searches in CANCERLIT and MEDLINE for oncologists. Journal of the National Cancer Institute. 74(6):1351-1353.

Reveiz Herault, L., et al. 2002. Cáncer e internet. Une studio descriptivo de los ensayos clínicos sobre cáncer encontrados en MEDLINE y CANCERLIT a través de Internet. Rev. Colomb. Cancerol. 6(2):20-27. Spanish.

CCRIS (Chemical Carcinogens Research Information System)

CEBS (Chemical Effects in Biological Systems)

Fostel J. M. 2008. Towards standards for data exchange and integration and their impact on a public database such as CEBS (Chemical Effects in Biological Systems). Toxicology & Applied Pharmacology. 233(1):54-62.

Fostel J.M., et al. 2005. Chemical Effects in Biological Systems—Data Dictionary (CEBS-DD): A compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and ‘Omics data. Toxicological Sciences. 88(2):585-601.

Waters M. 2003. Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base. Environmental Health Perspectives. 111(6):811.

Waters M., et al. 2008. CEBS—Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data. Nucleic Acids Research. 36(S1): D892-D900.

Xirasagar S., et al. 2006. Chemical effects in biological systems (CEBS) object model for toxicology data, SysTox-OM: design and application. Bioinformatics. 22(7):874-882.

CESARS (Chemical Evaluation Search & Retrieval System)


Gaulton A., et al. 2012. ChEMBL: A large-scale bioactivity database for drug discovery. Nucleic Acids Research. 40: D1100–D1107.

Chemical Abstracts

Jenkins J.A. 1992. Undergraduate instruction in online searching of Chemical Abstracts. Journal of Chemical Education. 69(8):639.

Moody R.L. and Zahm B.C. 1980. Chemical Abstracts as a resource for health and safety related chemical information. Journal of Chemical Information & Computer Science. 20(1):12-4.

Oide N. and Moriwaki N. 1990. Comparisons of indexing words used in CAB ABSTRACTS and AGRIS. Bulletin of the Japan Association of Agricultural Librarians & Documentalists. (78):1-10.

Roth D. 1998. Caveat chemicus: practical guidance to searching Chemical Abstracts. Searcher. 6(3):12,14, 16-17.

Roth D. 1998. Inexpensive structure searching: expanding chemical names. Searcher. 6(7):19-22.

Somerville A.N. 1993. Subject searching of Chemical Abstracts online—searching in the basic index. Journal of Chemical Education. 70:200-203.


Holmes J.C. 2008. JCE ChemInfo Collection of the JCE Digital Library. Journal of Chemical Education. 85(4):590.

Reich H.J. 2005. Introducing JCE ChemInfo: Organic. Journal of Chemical Education. 82(3): 495.


Bronson R.J. 1992. Two Chemical Dictionary Files: CHEMLINE and CHEMID. Medical Reference Services Quarterly. 11(1):1-16.

Schultheisz R.J., et al. 1978. Design and implementation of an on‐line chemical dictionary (CHEMLINE). Journal of the American Society for Information Science. 29(4):173-179.

Spann M.L., et al. 1978. CHEMLINE: A Chemical Structure Search Key to Biological Information. RN. 553:24-2.


Codex Alimentarius

Avery N., et al. 1993. Codex Alimentarius. Who is allowed in? Who is left out? Ecologist. 23(3):110-112.

Demortain D. 2012. Enabling global principle‐based regulation: The case of risk analysis in the Codex Alimentarius. Regulation & Governance. 6(2):207-224.

Hathaway S.C. 1993. Risk assessment procedures used by the Codex Alimentarius Commission and its subsidiary and advisory bodies. Food Control. 4(4):189-201.

Livermore M.A. 2006. Authority and legitimacy in global governance: Deliberation, institutional differentiation, and the Codex Alimentarius. New York University Law Review. 81:766.

Millstone E. and Van Zwanenberg P. 2002. The Evolution of Food Safety Policy–making Institutions in the UK, EU and Codex Alimentarius. Social Policy & Administration. 36(6):593-609.

Poli S. 2004. The European Community and the adoption of international food standards within the Codex Alimentarius Commission. European Law Journal. 10(5):613-630.

Randell A. 1995. Codex Alimentarius: how it all began. Food, Nutrition and Agriculture. 13-14:35-40.

Randell A. and Whitehead A.J. 1997. Codex Alimentarius: food quality and safety standards for international trade. Revue scientifique et technique (International Office of Epizootics). 16(2):313-321.

Somogyi A., et al. 2011. Scientific issues related to Codex Alimentarius goals: a review of principles, with examples. Regulatory Toxicology & Pharmacology. 60(1):161-164.

Winickoff D.E. and Bushey D.M. 2010. Science and power in global food regulation: the rise of the codex alimentarius. Science, Technology & Human Values. 35(3):356-381.

Comparative Toxicogenomics Database

Davis A.P., et al. 2013. The Comparative Toxicogenomics Database: Update 2013. Nucleic Acids Research. 41: D1104–D1114.

Concise International Chemical Assessment Documents

CPDB (Carcinogenic Potency Database)

Cunningham A.R., et al. 1998. Identification of genotoxic and non-genotoxic alerts for cancer in mice: the carcinogenic potency database. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 398(1):1-17.

Gold L.S., et al. 1984. A carcinogenic potency database of the standardized results of animal bioassays. Environmental Health Perspectives. 58:9-319.

Gold L.S., et al. 1987. Second chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environmental Health Perspectives 74:237-329.

Gold L.S., et al. 1986. Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environmental Health Perspectives. 67:161-200.

Gold L.S., et al.1989. Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database. Environmental Health Perspectives. 79:259-272.

Gold L.S., et al. 1990. Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environmental Health Perspectives. 84:215-216.

Gold L.S., et al. 1991. The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the US National Cancer Institute/National Toxicology Program. Environmental Health Perspectives. 96:11-15.

Gold L.S., et al. 1993. The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environmental Health Perspectives. 100:65-168.

Gold L.S., et al. 1995. Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993. Environmental Health Perspectives. 103(S8)3-122.

Gold L.S., et al. 1998. What do animal cancer tests tell us about human cancer risk? Overview of analyses of the carcinogenic potency database. Drug Metabolism Reviews. 30(2):359-404.

Gold L.S., et al. 1999. Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996. Environmental Health Perspectives. 107(S4):527-600.

Gold L.S., et al. 2005. Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997–1998. Toxicological Sciences. 85(2):747-808.

CRIS (Current Research Information System)

CTCP (Clinical Toxicology of Commercial Products)

Lee W.R. 1964. Clinical toxicology of commercial products. British Journal of Industrial Medicine. 21(3):249.

CTD (Comparative Toxicogenomics Database)

Davis A.P., et al. 2011. The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database. Database. 2011:034.

Davis A.P., et al. 2012. MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database. Database (Oxford) 2012: bar065.



DART (Developmental Toxicology Literature)


Combes R.D. and Rodford R.A. 2004. The Use of Expert Systems for Toxicity Prediction: Illustrated with Reference to the DEREK Program. In Cronin M. and Livingstone D. editors. Predicting Chemical Toxicity and Fate. Boca Raton, FL: CRC Press. Pages 194-203.

Greene N., et al. 1999. Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR. SAR and QSAR in Environmental Research. 10(2-3):299-314.

Sanderson D.M. and Earnshaw C.G. 1991. Computer prediction of possible toxic action from chemical structure; the DEREK system. Human & Experimental Toxicology. 10(4):261-273.


DESTAF (Dragon Exploration System for Toxicants & Fertility)

Dawe A.S., et al. 2012. DESTAF: A database of text-mined associations for reproductive toxins potentially affecting human fertility. Reproductive Toxicology. 33(1):99-105.

Dietary Exposure Potential Model

Tomerlin J.R., et al. 1996. Development of a Dietary Exposure Potential Model for evaluating dietary exposure to chemical residues in food. Journal of Exposure Analysis & Environmental Epidemiology. 7(1):81-101.


Goldsmith M.R., et al. 2008. DockScreen: A database of in silico biomolecular interactions to support computational. Environmental Health Perspectives. 116:573-577.

DOSE (Dictionary of Substances and their Effects)


Knox C., et al. 2011. DrugBank 3.0: a comprehensive resource for ‘omics’ research on drugs. Nucleic Acids Research. 39(S1): D1035-D1041.

Wishart D.S. 2008. DrugBank and its relevance to pharmacogenomics. Future Medicine. 9(8):1155-1162.

Wishart D.S. 2010. DrugBank: a general resource for pharmaceutical and pharmacological research. Molecular & Cellular Pharmacology. 2(1):25-38.

Wishart D.S., et al. 2006. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Research. 34(S1): D668-D672.


Richard. AM. 2004. DSSTox update & future plans. QSAR and Modeling Society Newsletter. 15: 34–36.

Richard A.M. 2004. DSSTOx web site launch: improving public access to databases for building structure-toxicity prediction models. Preclinica. 2(2):103-108.

Richard A.M. and Williams C.R. 2002. Distributed structure-searchable toxicity (DSSTox) public database network: a proposal. Mutation Research: New Frontiers. 499:27-52.

Williams-DeVane C.R., et al. 2009. DSSTox chemical-index files for exposure-related experiments in ArrayExpress and Gene Expression Omnibus: enabling toxico-chemogenomics data linkages. Bioinformatics. 25(5):692-694.



EADB (Estrogenic Activity Database)

Shen J., et al. 2013. EADB: an estrogenic activity database for assessing potential endocrine activity. Toxicological Sciences. 135(2):277-291.

EAFUS (USFDA-CFSAN Food Additive Database)

Benz R.D. and Irausquin H. 1991. Priority-based assessment of food additives database of the US Food and Drug Administration Center for Food Safety and Applied Nutrition. Environmental Health Perspectives. 96:85.

Daniel R. and Irausquin H. 1991. Priority-Based Assessment of food additives database of the U.S. Food and Drug Administration. Environmental Health Perspectives. 96:85-89.

EASE Model

Creely K.S., et al. 2005. Evaluation and further development of the EASE model 2.0. Annals of Occupational Hygiene. 49:135–45

Tickner J., et al. 2005. The development of the EASE model. Annals of Occupational Hygiene. 49(2):103-110.

ECETOC Aquatic Toxicity Database

Solbé J., et al. 1998. Analysis of the ECETOC Aquatic Toxicity (EAT) database I—general introduction. Chemosphere. 36(1):99-113.

Länge R., et al. 1998. Analysis of the ECETOC aquatic toxicity (EAT) database II—Comparison of acute to chronic ratios for various aquatic organisms and chemical substances. Chemosphere. 36(1):115-127.


Ahmed H. and Häder D.P. 2010. ECOTOX: a versatile tool for biomonitoring of aquatic ecosystems. Environmental Research Journal. 4(1/2):1-24.

Halling-Sørensen, B., et al. 1994. Application of the software Ecotox on agricultural chemicals. Ecological Modelling. 75:541-552.

Jun H., et al. 1999. Ecotox threshold and Its Application in American Superfund Program. Environment Herald. 6:001.

Poore L.M., et al. 2001. Toxicology information resources at the Environmental Protection Agency. Toxicology. 157(1):11-23.

EDKB (Endocrine Disrupter Knowledge Base)

Ding D., et al. 2010. The EDKB: An established knowledge base for endocrine disrupting chemicals. BMC Bioinformatics. 11(S6): S5


EINECS (European Inventory of Existing Commercial Chemical Substances)

ELNCS (European List of Notified Chemical Substances)


Brown C.M. 1998. The benefits of searching EMBASE versus MEDLINE for pharmaceutical information. Online and CD-Rom Review. 22(1):3-8.

Collins A.M. and Gass S. 1987. Searching EMBASE: do the results justify the cost? Health Libraries Review. 4(4):225-231.

Gretz M., et al. 1996. EMBASE remains EMBASE—on every host? A comparative analysis of EMBASE on the hosts DATA-STAR, DIALOG, DIMDI, and STN. Computers & Biomedical Research. 29(6):494-506.

Wilczynski N.L. and Haynes R.B. 2005. EMBASE search strategies for identifying methodologically sound diagnostic studies for use by clinicians and researchers. BMC Medicine. 3(1):1.


Lorent J-P. and Schirner H. 1978. An attempt to compare EMCS with TOXLINE. Online Review. 2(2):155-62.

EMIC (Environmental Mutagen Information Center)


Environmental Contaminants Encyclopedia (National Park Service)

Environmental Fate Database

Environmental Health Criteria Monographs

ERED (USACE Environmental Residue Effects Database)


Van Hemmen J.J. 2001. EUROPOEM, a predictive occupational exposure database for registration purposes of pesticides. Applied Occupational & Environmental Hygiene. 16(2):246-250.

European Centre for Ecotoxicology and Toxicology of Chemicals Join Assessment of Commodity Chemicals

European Centre for Ecotoxicology and Toxicology of Chemical Monographs

European Chemical Industry Council Emergency Response Intervention Cards

EUSES (European System for the Evaluation of Substances)

Vermeire T.G., et al. 1997. European union system for the evaluation of substances (EUSES). Principles and structure. Chemosphere. 34(8):1823-1836.



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