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A Small Dose of Pregnancy and Developmental


  • An Introdouction into the Effects on Pregnancy and Developmental

"Nature creates monsters for the purpose of astonishing us and amusing herself". Pliny (61–105 A.D.)

Pregnancy and Developmental Chapter


PowerPoint presentation


Examples of chemicals that affect reproduction


Class of chemical Examples
Endocrine disruptors DDT, Dioxin, phthalates
Heavy metals Lead (decreased or abnormal sperm)
Organic Solvents Toluene, benzene, n-Hexane
Drugs Alcohol, narcotics, hypotensive drugs, chemotherapeutic agents, steroids, diethylstibestrol
Pesticides dibromochloropropane (DBCP), methoxychlor, linuron (herbicide)
Disease Diabetes

Agents and chemicals that affect the developing infant


Metals Lead, Methylmercury, Arsenic (in animals)
Chemicals Chlorobiphenyls, Solvents (Toluene), Endocrine disruptors (DDT, TCDD)
Radiation X-rays (therapeutic), Atomic fallout
Infections Rubella virus, Herpes simplex virus, Toxoplasmosis, Syphilis
Medical Drugs Antibiotics (tetracylines), Anticancer drugs, Anticonvulsants (Valproic Acid), Lithium, Retinoids (Vitamin A), Thalidomide, Diethylstilbestrol (DES), Anticoagulants (Warfarin)
Recreational Drugs Alcohol (ethanol), Tobacco, Cocaine, Solvent abuse
Plants Many herbs, Skunk cabbage (Veratrum californicum) – sheep & cattle, Parasites (frogs)

More Information and References


European, Asian, and international Agencies


  • WHO Pregnancy. (accessed: 26 July 2009). Information from World Health Organization on efforts to improve pregnancy outcome.

North American Agencies


  • US National Children’s Study. (accessed: 26 July 2009) “The National Children’s Study will examine the effects of environmental influences on the health and development of 100,000 children across the United States, following them from before birth until age 21. The goal of the Study is to improve the health and well-being of children.”

Non-Government Organizations


  • Teratology Society. Accessed: 26 July 2009). “The Teratology Society is a multidisciplinary scientific society founded in 1960, the members of which study the causes and biological processes leading to abnormal development and birth defects at the fundamental and clinical level, and appropriate measures for prevention.”
  • March of Dimes. (accessed: 26 July 2009). “March of Dimes works to “give all babies a fighting chance against the threats to their health: prematurity, birth defects, low birth weight.”

Reference


  • Riddle, John M. Eve's Herbs: A History of Contraception and Abortion in the West., Harvard University Press; Cambridge, Mass 1999, 352 pages.
  • World Health Organization, Geneva Switzerland. Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals. Environmental Health Criteria 237 (2007). http://www.who.int/ipcs/publications/ehc/ehc237.pdf. (accessed: 26 July 2009). This volume addresses the unique vulnerability of children to social economic factors, nutrition, environmental chemicals and other hazards.
  • Hood, R.D. (2005) Developmental and Reproductive Toxicology: A Practical Approach, 2nd edition CRC Press, Boca Raton, FL

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