A Small Dose of Pregnancy and Developmental
- An Introdouction into the Effects on Pregnancy and Developmental
"Nature creates monsters for the purpose of astonishing us and amusing herself". Pliny (61–105 A.D.)
Pregnancy and Developmental Chapter
- A Small Dose of Pregnancy and Developmental - chapter pdf
PowerPoint presentation
- A Small Dose of Pregnancy and Developmental - PowerPoint presentation (2.3 mgb)
Examples of chemicals that affect reproduction
| Class of chemical | Examples |
|---|---|
| Endocrine disruptors | DDT, Dioxin, phthalates |
| Heavy metals | Lead (decreased or abnormal sperm) |
| Organic Solvents | Toluene, benzene, n-Hexane |
| Drugs | Alcohol, narcotics, hypotensive drugs, chemotherapeutic agents, steroids, diethylstibestrol |
| Pesticides | dibromochloropropane (DBCP), methoxychlor, linuron (herbicide) |
| Disease | Diabetes |
Agents and chemicals that affect the developing infant
| Metals | Lead, Methylmercury, Arsenic (in animals) |
| Chemicals | Chlorobiphenyls, Solvents (Toluene), Endocrine disruptors (DDT, TCDD) |
| Radiation | X-rays (therapeutic), Atomic fallout |
| Infections | Rubella virus, Herpes simplex virus, Toxoplasmosis, Syphilis |
| Medical Drugs | Antibiotics (tetracylines), Anticancer drugs, Anticonvulsants (Valproic Acid), Lithium, Retinoids (Vitamin A), Thalidomide, Diethylstilbestrol (DES), Anticoagulants (Warfarin) |
| Recreational Drugs | Alcohol (ethanol), Tobacco, Cocaine, Solvent abuse |
| Plants | Many herbs, Skunk cabbage (Veratrum californicum) – sheep & cattle, Parasites (frogs) |
More Information and References
European, Asian, and international Agencies
- European Teratology Society (ETS). (accessed: 26 July 2009). The society is dedicated to the prevention of adverse effects on reproduction and development.
- The Thalidomide Victims Association of Canada. (accessed: 26 July 2009). Information on thalidomide in English or French.
- WHO Pregnancy. (accessed: 26 July 2009). Information from World Health Organization on efforts to improve pregnancy outcome.
North American Agencies
- Center for the Evaluation of Risks to Human Reproduction (CERHR) - The National Toxicology Program. (accessed: 26 July 2009). CERHR web site has “information about potentially hazardous effects of chemicals on human reproduction and development.”
- US National Library of Medicine – Current Bibliographies in Medicine 97-4 – Thalidomide: Potential Benefits and Risks. (accessed: 26 July 2009). The NLM site contains an extensive bibliography on thalidomide.
- US Food and Drug Administration - Center for Food Safety and Applied Nutrition – Information for Pregnant Women (accessed: 26 July 2009) This FDA web site contains an extensive for pregnant women.
- US Department of Health and Human Services – healthfinder – Information for Pregnant Women. (accessed: 26 July 2009) Site contains general information and links on pregnancy and fetal development for men and women.
- US Centers for Disease Control and Prevention (CDC) – Health Topic: Pregnancy. (accessed: 26 July 2009) Site contains information and links on pregnancy and fetal development.
- US National Children’s Study. (accessed: 26 July 2009) “The National Children’s Study will examine the effects of environmental influences on the health and development of 100,000 children across the United States, following them from before birth until age 21. The goal of the Study is to improve the health and well-being of children.”
- California – Office of Environmental Health Hazard Assessment – Proposition 65. (accessed: 26 July 2009) Passed in 1986 by the voters of California, Proposition 65 “requires the Governor to publish, at least annually, a list of chemicals known to the state to cause cancer or reproductive toxicity”.
Non-Government Organizations
- Teratology Society. Accessed: 26 July 2009). “The Teratology Society is a multidisciplinary scientific society founded in 1960, the members of which study the causes and biological processes leading to abnormal development and birth defects at the fundamental and clinical level, and appropriate measures for prevention.”
- Society for Developmental Biology. (accessed: 26 July 2009). “The purpose of the Society is to further the study of development in all organisms.”
- March of Dimes. (accessed: 26 July 2009). “March of Dimes works to “give all babies a fighting chance against the threats to their health: prematurity, birth defects, low birth weight.”
Reference
- Riddle, John M. Eve's Herbs: A History of Contraception and Abortion in the West., Harvard University Press; Cambridge, Mass 1999, 352 pages.
- World Health Organization, Geneva Switzerland. Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals. Environmental Health Criteria 237 (2007). http://www.who.int/ipcs/publications/ehc/ehc237.pdf. (accessed: 26 July 2009). This volume addresses the unique vulnerability of children to social economic factors, nutrition, environmental chemicals and other hazards.
- Hood, R.D. (2005) Developmental and Reproductive Toxicology: A Practical Approach, 2nd edition CRC Press, Boca Raton, FL
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