Get your copy - FREE


Resources


Toxipedia Supported Sites


Animal and Plant Toxins

A Small Dose of Animal and Plant Toxins


  • An Introduction to the Health Effects of Animal and Plant Toxins
    • Ancient Greek Athletes - "The Greek physician Galen is reputed to have prescribed 'the rear hooves of an Abyssinian ass, ground up, boiled in oil, and flavored with rose hips and rose petals' to improve performance."
    • 399 BCE Death of Socrates by Hemlock Charged with religious heresy and corrupting the morals of local youth. Active chemical is the alkaloid coniine which when ingested causes paralysis, convulsions and potentially death.
    • Bee Stings - A honey bee has about 150µg of poison, but only a small fraction is typically injected. The faster the stinger is removed the less the response.

Animal and Plant Toxins Dossier


Dossier - Animal Toxin

  • Name: Animal Venoms and Poisons
    • Use: medicinal uses
    • Source: spiders, insects, snakes, lizards, fish, and frogs
    • Recommended daily intake: none (not essential)
    • Absorption: varies but can be very fast, e.g. bites
    • Sensitive individuals: children (small size), previously sensitized
    • Toxicity/symptoms: varies
    • Regulatory facts: none
    • General facts: long history of use and desire to avoid, often accompanied by fear of the animal
    • Environmental: global distribution, concern about expanding distribution to new areas
    • Recommendations: follow precautions for avoiding contact

Dossier - Pant Toxin

  • Name: Plant
    • Use: medicinal uses
    • Source: wide variety of plants
    • Recommended daily intake: none (not essential)
    • Absorption: intestine, skin
    • Sensitive individuals: children (small size), previously sensitized
    • Toxicity/symptoms: varies
    • Regulatory facts: none
    • General facts: long history of use and desire to avoid
    • Environmental: global distribution, concern about expanding distribution to new areas
    • Recommendations: generally avoid; know the poisonous plants in area


Animal and Plant Toxins Chapter


PowerPoint presentation


Arachnids (Scorpions, Spiders, Ticks)

Class Examples Delivery & Venom Comments
Arachnids (scorpions & spiders & ticks) Scorpions Stinger - neurotoxin, no enzymes Localized pain, mostly dangerous to children
  Latrodectus - Widow spiders (back, brown red-legged spider) Bite - neurotoxin - large molecular proteins Localized pain, sweating, muscle cramps, decreased blood pressure
  Loxosceles - Brown or Violin Spiders Bite - complex mixture of enzymes Serious tissue damage & attacks blood cells
  Ticks Bite - saliva neurotoxin - transmit other diseases Tick paralysis - weakness & difficulty walking - Remove tick

Insects

Examples Poison or Venom Comments
Moths and caterpillars Irritating substance Designed so they do not taste good
Ants Variable - proteins, formic acid and other Variable response - irritation, allergic response, tissue damage
Honey bees Complex proteins Swelling, allergic reaction
Wasps Formic acid Irritating

Reptiles

Class Examples Venom & Delivery Symptoms
Vipers (Viperidae) Rattlesnakes, Water moccasins, Copperheads, Bushmasters Very complex enzymatic based, advanced delivery - hinged tubular fangs Swelling & necrosis at site, affects blood cells, hemorrhage, decreased blood pressure, shock
Elapidae Cobras, Kraits, Coral Snakes Neurotoxin (some very potent) Fixed fangs, usually low dose Nervous system effects, paralysis, numbness, respiratory failure

Marine Animals

Animal Class Examples Toxin Symptoms Comment
Shellfish (filter-feeding mollusks) Mussels, clams, oysters, scallops Several kinds of toxin taken up from plankton (dinoflagellate) See below  
  Paralytic Shellfish Poisoning (PSP) saxitoxin in their muscles Numbness, respiratory paralysis Na channel permeability
  Diarrheic Shellfish Poisoning (DSP) high molecular weight polyethers Nausea, vomiting, diarrhea Usually mild but annoying
  Neurotoxic Shellfish Poisoning (NSP) brevetoxins Numbness of mouth, muscular aches, dizziness  
  Amnesic Shellfish Poisoning (ASP) domoic acid Confusion, memory loss, seizure, coma Affects elderly
Coelenterates Jelly fish, anemona, coral nematocyst sting, muscle cramps  
Fish Sea Snail (cigua) and some fish, oysters and clams Ciguatera, scaritoxin and maitotoxin Numbness, salivation, cardiovascular effects, respiratory paralysis inhibits acetyl cholinesterase
Fish Puffer Fish (fugu, blowfish, toadfish ... some frogs, starfish, octopus tetrodotoxin Nervous system Numbness, paralysis, respiratory failure, death Decreased Na channel permeability
Fish Tuna, shark, sword fish Mercury (toxicant) Neurotoxic, reproductive effects Not produced by fish itself, concentrated in muscle

Effects on Skin

Organ System Symptoms Plant Examples Toxin / Comment
Skin Allergic Dermatitis - Plant - Rashes, itchy skin Philodendron, poison ivy, cashew, bulbs of daffodils, hyacinths, tulips Antibody mediated after initial sensitization, very variable response. Allergens located on outer cells of plant
  Allergic Dermatitis - Pollen - Sniffles & sneezing, runny eyes Ragweed (North America), Mugwort (Europe), grasses Antibody mediated - Pollen widely distributed in air. Very common, can be debilitating
  Contact Dermatitis, Oral - Swelling and inflammation of mouth, skin - pain & stinging sensation Dumb cane (Dieffenbachia), Nettles (Urtica) Calcium oxalate crystals coated with inflammatory proteins, Fine tubes contain histamine, acetylcholine and serotonin

Gastrointestinal System

Organ System Symptoms Plant Examples Toxin / Comment
Gastrointestinal Direct stomach irritation - Nausea, vomiting and diarrhea California buckthorn (sacred bark), tung nut, horse chestnut, pokeweed ... Emodin & esculine (toxins); Oil from seeds, nuts; some medical uses, Children are most often affected
  Antimitotic (stops cell division) - Nausea, vomiting, confusion, delirium Lily family, glory lily, crocus, may apple Colchicine (gout treatment)
  Lectin toxicity - nausea, diarrhea, headache, confusion, dehydration, death Wisteria, castor bean (Ricinus communis) Lectins bind to cell surfaces, Ricin - block protein synthesis, very toxic: 5 to 6 beans can kill a child

Cardiovascular System

Organ System Symptoms Plant Examples Toxin / Comment
Cardiovascular Digitalis-like glycosides - cardiac arrhythmias Foxglove (Digitalis purpurea), squill, lily of the valley Contain glycosides that are similar to digitalis:scillaren, convallatoxin
  Heart nerves - decreased heart rate and blood pressure, general weakness Lily, hellebore, death camas, heath family, monkshood, rhododendron Alkaloids, aconitum, grayanotoxin (concentrated in honey)
  Blood vessel constriction (vasoconstriction) Mistletoe (berries contain toxin) Holy or demonic - effects on heart first described in 1597. Toxin is called phoratoxin.

Nervous system

Organ System Symptoms Plant Examples Toxin / Comment
Nervous System Seizures Water hemlock, (parsley family), mint family Cicutoxin - affects potassium channels. Monoterpenes in mint oils
  Stimulation - Excitatory Amino Acids - headache, confusion, hallucinations Red alga (red tide), Green alga, Mushrooms- Amanita family (fly agaric), Flat Pea (Lathyrus) Kainic acid, domoic acid-concentrated in shell fish, Ibotenic acid, muscarinic, (hallucinations), Latthyrism - motor neuron degeneration
  Aberrant behavior, very excitable, muscle weakness, death Locoweed - Australian & Western U.S. plant Swainsonine toxin - liver enzyme inhibitor - well known to affect cattle
  Stimulation Coffee bean, tea, cola nut, Caffeine, most widely consumed stimulant in the world
  Neurotoxic - death Poison hemlock (Conium maculatum) Coniine - neurotoxic alkaloid - Poison used by Socrates
  Paralysis - demyelination of peripheral nerves Buckthorn, coyotillo, tullidora, (U.S., Mexico) Anthracenones - attack the myelin that surrounds the peripheral nerves
  Atropine-like effects - dry mouth, dilated pupils, confusion, hallucinations, memory lose Solanaceae family - jimsonweed, henbane, deadly nightshade (Atropa belladonna), angles trumpet (atropine and scopolamine) Clinical effects of many of the plants recognized since ancient times. Deaths are rare but children vulnerable.
Hallucinations from muscarine & psilocybin
  Neuromuscular - mild stimulation to muscle paralysis, respiratory failure (curare), death Tobacco - South American - Strychnos family (curare), Blue green alga (anatonin A) Nicotine -blocks acetylcholine receptors, Curare - used as a hunting poison very potent receptor blocker

Liver

Organ System Symptoms Plant Examples Toxin / Comment
Liver "Hepatitis" and cirrhosis of liver - From contaminated grain Ragwort or groundsel Pyrrolizidine alkaloids - attack liver vessels - effects humans, cattle but some species resistant
  Liver failure and death Mushrooms - "Death cap" (Amanita phalloides) Amatoxin and phalloidin effects RNA and protein synthesis
  Liver cancer Fungus that grows on peanuts, walnuts, etc... Alfaltoxins- produced by fungus in poorly stored grain

Reproductive Effects

Organ System Symptoms Plant Examples Toxin / Comment
Reproductive Effects Teratogen - malformations in offspring (sheep) Veratrum californicum - native to North America Veratrum - blocks cholesterol synthesis - seen offspring of mountain sheep
  Abortifacients - cause fetal abortions Legumes (Astrogalus), Bitter melon seeds (Momordica) Swainsonine toxin - stops cell division, Lectins - halt protein synthesis- used by humans

More Information and References


European, Asian, and international Agencies


North American Agencies


  • Health Canada - Natural Health Products Directorate (accessed: 16 June 2009).
    Natural Health Products Directorate works to "ensure that all Canadians have ready access to natural health products that are safe, effective, and of high quality, while respecting freedom of choice and philosophical and cultural diversity".
  • Northwest Fisheries Science Center's (NWFSC) Harmful Algal Bloom Program (accessed: 16 June 2009).
    NWFSC Harmful Algal Bloom Program, part of the U.S. National Oceanic and Atmospheric Administration, provides information related to algal blooms.

Non-Government Organizations


  • Natural Toxins Research Center (NTRC) - Texas A&M University System (accessed: 16 June 2009).
    NTRC provides global research, training, and resources that will lead to the discovery of medically important toxins found in snake venoms.
  • Cornell University - Plants Poisonous to Livestock (accessed: 16 June 2009).
    This is "includes plant images, pictures of affected animals and presentations concerning the botany, chemistry, toxicology, diagnosis and prevention of poisoning of animals by plants and other natural flora (fungi, etc.)".
  • Alternative Medicine Foundation, Inc, HerbMed® (accessed: 16 June 2009).
    "HerbMed® - an interactive, electronic herbal database - provides hyperlinked access to the scientific data underlying the use of herbs for health. It is an evidence-based information resource for professionals, researchers, and general public."
  • The Vaults of Erowid (accessed: 16 June 2009).
    The Vaults of Erowid web site contains information on wide variety of natural plants and chemicals.

References


  • Handbook of Clinical Toxicology of Animal Venoms and Poisons
    by J. Meier (Editor), Julian White (Editor), Informa HealthCare, 768 pages, 1995.
  • Venomous and Poisonous Animals: A Handbook for Biologists, Toxicologists and Toxinologists, Physicians and Pharmacists. by Dietrich Mebs, Medpharm 360 pages, 2002.

Labels:

Enter labels to add to this page:
Wait Image 
Looking for a label? Just start typing.